4,653 research outputs found
Data Science as an Emerging Discipline: The Roles of iSchools in the Era of Big Data
Workshop 4b: Information Science to Data Science: New Directions for iSchools Part 2 of 2 - Session 2A: Collaborative and Interdisciplinary Nature of IS2DSHosts: Wuhan University School of Information Management and the Sungkyunkwan University Library & Information Science and Data Science DepartmentData science has been a hype in both academia and industry. It is a high time for iSchools to reflect the roles they are playing and how they can contribute in the data science space, specifically in the areas of education and research. This position paper reviews data science related teaching and research activities in tier 1 iSchools and discusses the potentials of iSchools in shaping up the future of Data science.published_or_final_versio
Methods of tropical optimization in rating alternatives based on pairwise comparisons
We apply methods of tropical optimization to handle problems of rating
alternatives on the basis of the log-Chebyshev approximation of pairwise
comparison matrices. We derive a direct solution in a closed form, and
investigate the obtained solution when it is not unique. Provided the
approximation problem yields a set of score vectors, rather than a unique (up
to a constant factor) one, we find those vectors in the set, which least and
most differentiate between the alternatives with the highest and lowest scores,
and thus can be representative of the entire solution.Comment: 9 pages, presented at the Annual Intern. Conf. of the German
Operations Research Society (GOR), Helmut Schmidt University Hamburg,
Germany, August 30 - September 2, 201
Nonequilibrium Dynamics in Noncommutative Spacetime
We study the effects of spacetime noncommutativity on the nonequilibrium
dynamics of particles in a thermal bath. We show that the noncommutative
thermal bath does not suffer from any further IR/UV mixing problem in the sense
that all the finite-temperature non-planar quantities are free from infrared
singularities. We also point out that the combined effect of finite temperature
and noncommutative geometry has a distinct effect on the nonequilibrium
dynamics of particles propagating in a thermal bath: depending on the momentum
of the mode of concern, noncommutative geometry may switch on or switch off
their decay and thermalization. This momentum dependent alternation of the
decay and thermalization rates could have significant impacts on the
nonequilibrium phenomena in the early universe at which spacetime
noncommutativity may be present. Our results suggest a re-examination of some
of the important processes in the early universe such as reheating after
inflation, baryogenesis and the freeze-out of superheavy dark matter
candidates.Comment: 24 pages, 2 figure
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Minimizing the effects of unmodulated light and uneven intensity profile on the holographic images reconstructed by pixelated spatial light modulators
A simple and effective approach is proposed to minimize the effect of unmodulated light and uneven intensity caused by the pixelated structure of the spatial light modulator in a holographic display. A more uniform image is produced by purposely shifting the holographic images of multiple reconstructed lights with different incident angles from the zero-diffraction-order and overlapping those selected different orders. The simulation and optical experimental results show that the influence of the zero-diffraction-order can be reduced while keeping the good uniformity of the target images by this new approach.UK Engineering and Physical Sciences Research Council (EPSRC) through the EPSRC Centre for Innovative Manufacturing in Ultra Precision (EP/I033491/1
Lipoteichoic acid from an Enterococcus faecalis clinical strain promotes TNF-α expression through the NF-ÎșB and p38 MAPK signaling pathways in differentiated THP-1 macrophages
published_or_final_versio
Accommodation-Free Head Mounted Display with Comfortable 3D Perception and an Enlarged Eye-box.
An accommodation-free displays, also known as Maxwellian displays, keep the displayed image sharp regardless of the viewer's focal distance. However, they typically suffer from a small eye-box and limited effective field of view (FOV) which requires careful alignment before a viewer can see the image. This paper presents a high-quality accommodation-free head mounted display (aHMD) based on pixel beam scanning for direct image forming on retina. It has an enlarged eye-box and FOV for easy viewing by replicating the viewing points with an array of beam splitters. A prototype aHMD is built using this concept, which shows high definition, low colour aberration 3D augmented reality (AR) images with an FOV of 36°. The advantage of the proposed design over other head mounted display (HMD) architectures is that, due to the narrow, collimated pixel beams, the high image quality is unaffected by changes in eye accommodation, and the approach to enlarge the eye-box is scalable. Most importantly, such an aHMD can deliver realistic three-dimensional (3D) viewing perception with no vergence-accommodation conflict (VAC). It is found that viewing the accommodation-free 3D images with the aHMD presented in this work is comfortable for viewers and does not cause the nausea or eyestrain side effects commonly associated with conventional stereoscopic 3D or HMD displays, even for all day use
Flux Discharge Cascades in Various Dimensions
We study the dynamics of electric flux discharge by charged particle pair or
spherical string or membrane production in various dimensions. When electric
flux wraps at least one compact cycle, we find that a single "pair" production
event can initiate a cascading decay in real time that "shorts out" the flux
and discharges many units of it. This process arises from local dynamics in the
compact space, and so is invisible in the dimensionally-reduced truncation. It
occurs in theories as simple as the Schwinger model on a circle, and has
implications for any theory with compact dimensions and electric flux,
including string theories and the string landscape.Comment: 19+8 pages, 3 figures, 3 appendice
An adaptive prefix-assignment technique for symmetry reduction
This paper presents a technique for symmetry reduction that adaptively
assigns a prefix of variables in a system of constraints so that the generated
prefix-assignments are pairwise nonisomorphic under the action of the symmetry
group of the system. The technique is based on McKay's canonical extension
framework [J.~Algorithms 26 (1998), no.~2, 306--324]. Among key features of the
technique are (i) adaptability---the prefix sequence can be user-prescribed and
truncated for compatibility with the group of symmetries; (ii)
parallelizability---prefix-assignments can be processed in parallel
independently of each other; (iii) versatility---the method is applicable
whenever the group of symmetries can be concisely represented as the
automorphism group of a vertex-colored graph; and (iv) implementability---the
method can be implemented relying on a canonical labeling map for
vertex-colored graphs as the only nontrivial subroutine. To demonstrate the
practical applicability of our technique, we have prepared an experimental
open-source implementation of the technique and carry out a set of experiments
that demonstrate ability to reduce symmetry on hard instances. Furthermore, we
demonstrate that the implementation effectively parallelizes to compute
clusters with multiple nodes via a message-passing interface.Comment: Updated manuscript submitted for revie
Cryotomography of budding influenza a virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end
Influenza viruses exhibit striking variations in particle morphology between strains. Clinical isolates of influenza A virus have been shown to produce long filamentous particles while laboratory-adapted strains are predominantly spherical. However, the role of the filamentous phenotype in the influenza virus infectious cycle remains undetermined. We used cryo-electron tomography to conduct the first three-dimensional study of filamentous virus ultrastructure in particles budding from infected cells. Filaments were often longer than 10 microns and sometimes had bulbous heads at their leading ends, some of which contained tubules we attribute to M1 while none had recognisable ribonucleoprotein (RNP) and hence genome segments. Long filaments that did not have bulbs were infrequently seen to bear an ordered complement of RNPs at their distal ends. Imaging of purified virus also revealed diverse filament morphologies; short rods (bacilliform virions) and longer filaments. Bacilliform virions contained an ordered complement of RNPs while longer filamentous particles were narrower and mostly appeared to lack this feature, but often contained fibrillar material along their entire length. The important ultrastructural differences between these diverse classes of particles raise the possibility of distinct morphogenetic pathways and functions during the infectious process
Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.
Research Fund for the Control of Infectious Diseases: Research Dissemination Reports (Series 2)1. A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous L-SIGN demonstrated lower binding capacity for HIV1-gp120.3. Genetic-association studies for single nucleotide polymorphisms of the inflammatory response genes, namely TNF-alpha, INF-alpha, INF-beta, INF-gamma, IL1-alpha, IL1-beta, IL-4, IL-6 and iNOS, failed to show a significant association with SARS clinical outcomes or susceptibility.published_or_final_versio
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